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Super-mix Series
Classifier
Bioreactors
Realization of Industrialization / Commercial Production / Scalability
Microbial culture
HSF ReactorAnimal cell culture
MRF ReactorAnimal cell culture
MRF-RB ReactorAnimal cell culture
VMF ReactorAnimal cell culture
VerSus ReactorRegenerative medicine
VMF-WSUB Reactor/TCSSingle-use BioReactor
iPS cell culture
HiD4×4 ReactorFittings/Options
Solutions
Development of exclusive mixers・
and impellers by purpose of useContracted numerical calculation
Evaluation of contracted cell culture
Classification performance evaluation
Environmental testing equipment
Bioreactors
HSF Reactor
MRF Reactor
MRF-RB Reactor
VMF Reactor
VerSus Reactor
VMF-WSUB
Reactor/TCSSingleUse
BioReactorHiD4x4 Reactor
Fittings/Options
Animal cell BioReactor VMF Reactor
Vertical reciprocating motion type mixer for cell culture
Development, Customization, and Single-use support of Exclusive Reactor in Accordance with Requirements Specifications

With the help of the dedicated controller “S-BOX × 10α II”, changes in various parameters including PI control can be easily performed. Through customization, up to eight machines in series are supported.
Mixing impeller used exclusively for vertical reciprocating motion

VM100
VM200
Control of the shearing action and a good mixing action are both established, and an environment that is best suited for cell culture is created!!
■Comparison of shear stress

■Culture example

Comparison of cell culture by CHO cells
The VMF reactor provides cells with the optimal physical environment in the culture tank, creating a suitable tank environment for cell cultivation compared to rotational BioReactors, maintaining a high rate of living cells compared to MRF reactors.
Although this superior effect is weakened for cells that are resistant to shear damage, this product offers superior performance for cell culture that relies on shear damage. This results in increased productivity.
Item | Specifications | ||||
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Name | VMF Reactor | ||||
Model | VMF-500 | VMF-1500 | VMF-3000 | VMF-10000 | |
Temperature control method | Band heater (PID control) with anti-excessive temperature rise function (Max. 80 [℃]) | ||||
Power transmission | Linear shaft drive non-sealing type | ||||
Gas supply device | Sintered metal type *Optional | ||||
Performance | Temp. control range | Room temperature + 5 to 20℃ (normally set to 37℃) | |||
Temp. accuracy | ±0.3[℃](37[℃]) | ||||
Max. up/down motion amplitude | 40[mm] | ||||
Max. impeller speed | 300[mm/s] | ||||
Function | Temperature setting | Digital setting, data output 1 - 5 [V] | |||
Up/down motion setting | Touch panel input, data output 1 - 10 [V] | ||||
Configuration | Band heater | 60 [W] | 105 [W] | 160 [W] | 480 [W] |
Mixer motor | Max. power 800 [W] | ||||
Mixing impellers | [Standard] VM200 | [Standard] VM100+VM200 | |||
Culture tank | Dimensions | I.D. 90 x Depth 200 [mm] | I.D. 110 x Depth 169 [mm] | I.D. 140 x Depth 203 [mm] | I.D. 200 x Depth 360 [mm] |
Total capacity | 0.5[L] | 1.5[L] | 3[L] | 10[L] | |
Environment temp. range | 10~35[℃] | ||||
Outer dimensions | W360×H905×D485 [mm] | ||||
Weight | approx. 28[kg] | approx. 28[kg] | approx. 30[kg] | approx. 34[kg] | |
Power supply | AC 100[V]、50/60[Hz] | ||||
*The performance is the value under room temperature 20℃, power supply AC 100 [V], 50 [Hz] and no load condition. |
Item | Specifications | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Name | Culture controller | |||||||||||
Model | S-BOX×10αII | |||||||||||
Display range/accuracy | pH (Hydrogen ion concentration) | 0.00~14.00 [pH] | Display accuracy: F.S±0.5 [%] | |||||||||
DO (Dissolved oxygen) | 0.00~20.00 [mg/L] | |||||||||||
FL (O2flow rate) | 0.00~20.00 [mL/min] | |||||||||||
Setting range | pH (Hydrogen ion concentration) | 0.00~14.00 [pH] | ||||||||||
DO (Dissolved oxygen) | 0.00~10.00 [mg/L] | |||||||||||
FL (O2flow rate) | 0.00~20.00 [mL/min] | |||||||||||
Control output | pH (Hydrogen ion concentration) | ON/OFF control | ||||||||||
DO (Dissolved oxygen) | O2addition/subtraction step control | |||||||||||
O2and N2ON/OFF control | ||||||||||||
O2PI control (slope set method: time, %) | ||||||||||||
FL (O2flow rate) | PI control (slope set method: time, %) | |||||||||||
Data output | pH (Hydrogen ion concentration) | With data logger DC 0 - 5 [V] *Load factor can be put out. (optional) |
Accuracy: F.S±0.5 [%] | |||||||||
DO (Dissolved oxygen) | ||||||||||||
FL (O2flow rate) | ||||||||||||
Mixing frequency | ||||||||||||
Temperature | With data logger DC 1 - 5 [V] |
|||||||||||
Casing | SUS304 (no coating), indoor type, non-drip proof, non-explosion proof specification | |||||||||||
Installation | Indoor tabletop type | |||||||||||
Outer dimensions/weight | W350×H530×D400 [mm] ・ approx. 15[kg] | |||||||||||
Environment conditions | Temperature | 5~45 [℃] | Humidity | 20 - 85% RH (with no condensate) | ||||||||
Sensors | Standard accessories: Mettler Toledo company Polarographic DO sensor/pH sensor | |||||||||||
Option: Automatic System Research Co., Ltd. Optical DO sensor | ||||||||||||
Utilities | Power supply | AC100 [V] 50/60[Hz] electrical outlet × 2 (for controller unit and recorder) | ||||||||||
N2 | Flow rate 50 [mL/min] or lower Supply pressure 0.2 [MPa] Connection port φ6 tube one-touch joint |
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O2 | Flow rate 20 [mL/min] or lower, supply pressure 0.2 [MPa] Connection port φ6 tube one-touch joint |
|||||||||||
CO2 | Flow rate 50 [mL/min] or lower, supply pressure 0.2 [MPa] Connection port φ6 tube one-touch joint |
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AIR | Flow rate 150 [mL/min] or lower, supply pressure 0.2 [MPa] Connection port φ6 tube one-touch joint |
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*All of O₂, CO₂, and AIR must be dry gases that do not contain corrosive components, dust, and oil mist. |