Products & Services
List of products
Catalogs
Mixers
Small machines
Water treatment
Petrochemistry
Food & beverage
Medicines
Bio & regenerative medical techniques
Paints
Paper manufacturing
For experiments
Super-mix Series
Classifier
Bioreactors
Realization of Industrialization / Commercial Production / Scalability
Microbial culture
HSF ReactorAnimal cell culture
MRF ReactorAnimal cell culture
MRF-RB ReactorAnimal cell culture
VMF ReactorAnimal cell culture
VerSus ReactorRegenerative medicine
VMF-WSUB Reactor/TCSSingle-use BioReactor
iPS cell culture
HiD4×4 ReactorFittings/Options
Solutions
Development of exclusive mixers・
and impellers by purpose of useContracted numerical calculation
Evaluation of contracted cell culture
Classification performance evaluation
Environmental testing equipment
Bioreactors
HSF Reactor
MRF Reactor
MRF-RB Reactor
VMF Reactor
VerSus Reactor
VMF-WSUB
Reactor/TCSSingleUse
BioReactorHiD4x4 Reactor
Fittings/Options
VMF-WSUB Reactor/TCS Controller
Equipped with weight management perfusion system
for commercial regenerative medicine production
Development, Customization, and Single-use support of Exclusive Reactor in Accordance with Requirements Specifications

Patent No. 4316251
A perfusion system that makes long-term,
continuous culturing possible!
Long-term, clog-free operation
from undifferentiated cultures to differentiation!
■Load cell for culture tank weight measurement

Mixing BioReactors experience frequent weight fluctuations, and this production system makes it possible to accurately gauge only the target weight inside the culture tank as well as culture medium replacement and perfusion control.
■Culture medium replacement holder and membrane set MED-CH

This culture medium replacement holder and membrane set keeps the tank free from clogging for long periods of time and offers superb practical separation of cells and culture medium inside the tank.
There are several different types of membrane section depending on your purpose.
Item | Specifications | ||||
---|---|---|---|---|---|
Name | VMF-W Reactor | ||||
Model | VMF-500W | VMF-3000W | |||
Temperature control method | Band heater (PID control) with anti-excessive temperature rise function (Max. 60/80 [℃]) | ||||
Power transmission | Linear shaft drive non-sealing type | ||||
Gas supply device | Sintered metal type *Optional | ||||
Performance | Temp. control range | Room temperature + 5 ~ 20℃ (normally set to 37℃) | |||
Temp. accuracy | ±0.3 [℃] (37 [℃]) | ||||
Max. up/down motion amplitude | 40 [mm] | ||||
Max. impeller speed | 300 [mm/s] | ||||
Function | Temperature setting | Digital setting, data output 1 - 5 [V] | |||
Up/down motion setting | Touch panel input, data output 0 - 10 [V] | ||||
Configuration | Band heater | 40 [W] (anti-excessive temperature rise: 60[℃]) | 160 [W] (anti-excessive temperature rise: 80[℃]) | ||
Mixer motor | Max. power 800 [W] | ||||
Mixing impellers | [Standard] VM200 | [Standard] VM100+VM200 | |||
Culture tank | Dimensions | I.D. 94/87 x Depth 110 [mm] | I.D. 159/138 x Depth 202 [mm] | ||
Total capacity | 0.5[L] | 3[L] | |||
Environment temp. range | 10~35[℃] | ||||
Outer dimensions | W360×H905×D485 [mm] | ||||
Weight | approx. 28[kg] | approx. 30[kg] | |||
Power supply | AC 100[V]、50/60[Hz] | ||||
*The performance is the value under room temperature 20℃, power supply AC 100 [V], 50 [Hz] and no load condition. |
Item | Specifications | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Name | Culture controller | |||||||||||
Model | S-BOX×TCS | |||||||||||
Display range/accuracy | pH (Hydrogen ion concentration) | 0.00~14.00 [pH] | Display accuracy: F.S±0.5 [%] | |||||||||
DO (Dissolved oxygen) | 0.00~20.00 [mg/L] | |||||||||||
FL (O2flow rate) | 0.00~20.00 [mL/min] | |||||||||||
In-tank weight | 0~6118 [g] | |||||||||||
Supply balance weight W1 | -3200.00~3200.00 [g] | |||||||||||
Discharge balance weight W2 | -3200.00~3200.00 [g] | |||||||||||
Supply pump speed P1 | 0.0~200.0 [min-1] | |||||||||||
Discharge pump speed P2 | 0.0~200.0 [min-1] | |||||||||||
Setting range | pH (Hydrogen ion concentration) | 0.00~14.00 [pH] | ||||||||||
DO (Dissolved oxygen) | 0.00~10.00 [mg/L] | |||||||||||
FL (O2 flow rate) | 0.00~20.00 [mg/L] | |||||||||||
In-tank weight | 0~6118 [g] | |||||||||||
Supply balance weight W1 | -3200.00~3200.00 [g] | |||||||||||
Discharge balance weight W2 | -3200.00~3200.00 [g] | |||||||||||
Supply pump speed P1 | 0.0~200.0 [min-1] | |||||||||||
Discharge pump speed P2 | 0.0~200.0 [min-1] | |||||||||||
Control output | pH (Hydrogen ion concentration) | ON/OFF control | ||||||||||
DO (Dissolved oxygen) | O2addition/subtraction step control | |||||||||||
O2and N2ON/OFF control | ||||||||||||
O2PI control (slope set method: time, %) | ||||||||||||
FL (O2 flow rate) | PI control (slope set method: time, %) | |||||||||||
Fed-batch control (1) | Intermittent culture medium replacement control by in-tank weight and roller pump | |||||||||||
Continuous culture medium replacement control by in-tank weight and roller pump | ||||||||||||
Fed-batch control (2) | Intermittent culture medium replacement control by culture medium supply/discharge balance weight and roller pump | |||||||||||
Continuous culture medium replacement control by culture medium supply/discharge balance weight and roller pump | ||||||||||||
Data output | pH (Hydrogen ion concentration) | With data logger DC 0 - 5 [V] *Load factor can be put out. (optional) |
Accuracy: F.S±0.5 [%] | |||||||||
DO (Dissolved oxygen) | ||||||||||||
FL (O2 flow rate) | ||||||||||||
Mixing frequency | ||||||||||||
Temperature | With data logger DC 1 - 5 [V] | |||||||||||
In-tank weight | With data logger Digital input type |
|||||||||||
Supply/discharge balance weight | ||||||||||||
Supply/discharge pump speed | ||||||||||||
Casing | SUS304 (no coating), indoor type, non-drip proof, non-explosion proof specification | |||||||||||
Installation | Indoor tabletop type | |||||||||||
Outer dimensions/weight | W350×H538×D400 [mm] ・ approx. 26[kg] | |||||||||||
Environment conditions | Temperature | 5~45 [℃] | Humidity | 20 - 85% RH (with no condensate) | ||||||||
Sensors | Standard accessories: Mettler Toledo company Polarographic DO sensor/pH sensor | |||||||||||
Option: Automatic System Research Co., Ltd. Optical DO sensor | ||||||||||||
Utilities | Power supply | AC100 [V] 50/60[Hz] electrical outlet × 2 (for controller unit and recorder) | ||||||||||
N2 | Flow rate 50 [mL/min] or lower Supply pressure 0.2 [MPa] Connection port φ6 tube one-touch joint |
|||||||||||
O2 | Flow rate 20 [mL/min] or lower, supply pressure 0.2 [MPa] Connection port φ6 tube one-touch joint |
|||||||||||
CO2 | Flow rate 50 [mL/min] or lower, supply pressure 0.2 [MPa] Connection port φ6 tube one-touch joint |
|||||||||||
AIR | Flow rate 150 [mL/min] or lower, supply pressure 0.2 [MPa] Connection port φ6 tube one-touch joint |
|||||||||||
*All of O₂, CO₂, and AIR must be dry gases that do not contain corrosive components, dust, and oil mist. |