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Bioreactors
Realization of Industrialization / Commercial Production / Scalability
MRF Reactor
VMF Reactor
VerSus Reactor
Single-use BioReactor
HiD 4 × 4 Reactor
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Development of exclusive mixers・
and impellers by purpose of useContracted numerical calculation
Evaluation of contracted cell culture
Classification performance evaluation
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BioReactors
VerSus Reactor
Collaboration of VMF Reactor/SPG membrane sparger
Development, Customization, and Single-use support of Exclusive Reactor in Accordance with Requirements Specifications
Patent No. 4316251, Other patents have either being applied for or already registered
SPG membrane sparger
The micro-bubbles can be homogeneously dispersed inside the tank.
*SPG membrane sparger has been developed jointly by MIYAZAKI PREFECTURE INDUSTRIAL TECHNOLOGY CENTER and JGC Corporation.
We promise further improvement in production efficiency with the “VerSus Reactor” which is a collaboration of the “VMF Reactor” that controls the physical action in the cell culture tank and “SPG membrane sparger”, which is an excellent micro bubble technology.
■Culture example
Comparison of production of
antibodies by CHO cells
The growth curve of CHO cells based on the presence of SPG membrane sparger is shown by using the VMF reactor. It is understood that the culture results improves significantly by using the SPG membrane sparger. Due to micro-bubbles having extremely high homogeneity, the high gas absorption performance significantly reduces the DO air flow rate, which is the cause of formation of a foam layer, without disturbing the weak flow. VerSus reactor has a significantly improved total performance.
Comparison of production of
antibodies by CHO cells
The result* of scale-up from the control quantity of 8 l to 150 l by using CHO cells having high dependability on the shear stress is shown below. Here, the actually commercially-available production of antibodies is undertaken. As a result, in the 150-l scale-up condition, either almost the same or more volume of production of antibodies than the control quantity of 8 l was obtained. This scale-up is performed by the numerical fluid calculation at a constant shear factor, and its advantage in the combined use of computational fluid dynamics and cell culture has been proved.
* The result of joint research with JGC Corporation
| ■VerSus Reactor Specifications | |||||
|---|---|---|---|---|---|
| Item | Specifications | ||||
| Product name | VerSus Reactor | ||||
| Model | VSR-500 | VSR-1500 | VSR-3000 | VSR-10000 | |
| Temperature control type | Band heater method (PID control) with excessive temperature rise prevention function（MAX 80℃） | ||||
| Linear-motion transmission method | Linear shaft drive non-sealing type | ||||
| Ventilation type | Shirasu porous glass (SPG) membrane type | ||||
| Performance | Temperature regulation range | Room temperature+5～20℃(normally set to 37℃) | |||
| Temperature regulation accuracy | ±0.3℃(37℃) | ||||
| Max. up/down motion amplitude | 40ｍｍ | ||||
| Max. impeller speed | 300mm/s | ||||
| Function | Temperature setting | Digital setting | |||
| Up/down motion setting | Touch panel input | ||||
| Configuration | Band heater | 150W | |||
| Mixing motor | Max. output 800W | ||||
| Mixing impellers | Standard VM200 | Standard VM100 + VM200 | |||
| Standard | Culture tank dimensions | Inner diameter90 ×200Depth [mm] |
Inner diameter110 ×169Depth [mm] |
Inner diameter140 ×203Depth [mm] |
Inner diameter200 ×360sDepth [mm] |
| Culture tank total capacity | 0.5L | 1.5L | 3L | 10L | |
| Operating ambient temperature range | 10~35℃ | ||||
| Outer dimensions | 300W×485D×890H[mm] (When a fall prevention fitting has been attached、360W) | ||||
| Weight | Approx. 28kg | Approx. 28kg | Approx. 30kg | Approx. 34kg | |
| Rated power supply | AC-100V, 50/60Hz | ||||
* The performance is the value at a room temperature of 20℃, rated power supply voltage 100 VAC 50 Hz, during no load.
| ■S-BOX×10αSpecifications | |||
|---|---|---|---|
| Item | Specifications | ||
| Name | Culture controller | ||
| Model | S-BOX×10α | ||
| Display range / accuracy | pH | 0.00～14.00 [pH] | Display accuracy：F.S±0.5% |
| DO(Dissolved oxygen) | 0.00～10.00 [mg/L] | ||
| FL(O₂ flow rate) | 0.00～20.00 [mL/min] | ||
| Control setting range | pH | 0.00～14.00 [pH] | |
| DO(Dissolved oxygen) | 0.00～10.00 [mg/L] | ||
| FL(O₂ flow rate) | 0.00～20.00 [mL/min] | ||
| Control output | pH | ON/OFF control | |
| DO(Dissolved oxygen) | Flow rate addition/subtraction step control | ||
| FL(O₂ flow rate) | PI control (slope set method: Time, %) | ||
| Record output | pH | Data logger included DC 0～5 [V] |
Output accuracy：F.S±0.5% |
| DO(Dissolved oxygen) | |||
| FL(O₂ flow rate) | |||
| Power supply | AC 100 V, 50/60Hz | ||
| Case material | SUS304 （No coating） Indoor type, non-drip proof, non-explosion proof specification |
||
| Installation method | Indoor tabletop type | ||
| Outer dimensions | W260×Ｈ350×D300 [mm] | ||
| Ambient environment conditions | Temperature | 5~45 ℃ | |
| Humidity | 20~85 %（No dew formation） | ||
| Utility | Power supply | 100 VAC electrical outlet × 2 (for controller unit and recorder) | |
| O₂ | Flow rate 20 ml/min or less Supply pressure 0.3 MPa Connection port Φ6 tube one-touch joint |
||
| CO₂ | Flow rate 50 ml/min or less Supply pressure 0.2 MPa Connection port Φ6 tube one-touch joint |
||
| AIR | Flow rate 150 ml/min or less Supply pressure 0.2 MPa Connection port Φ6 tube one-touch joint |
||
* O₂, CO₂, and AIR must all be dry gases that do not contain corrosive components, dust, and oil mist |
|||
