Products & Services

Products & Services

Bioreactors

A single-use BioReactor

VMF Reactor 50L/200L-SUB

Development, Customization, and Single-use support of Exclusive Reactor in Accordance with Requirements Specifications

A single-use BioReactor

Patent No. 4316251,
Other patent pending or registered

The VMF50L/200L-SUB is a single-use BioReactor for commercial production. A lineup of 50L to 200L (proposed to be developed up to 1000L) is available, and single-use bag that supports sterilization validation is adopted. Since this is a locally-manufactured product, we guarantee just-in-time supply in small lots. With the help of the dedicated controller “S-BOX × 200”, changes in various parameters including PI control can be easily performed.

Bag for single use

Bag for single use
  • ・Since this is a 100% local product,
    we can always provide a stable supply even in small lots.
  • ・Since sterilization has already been performed, you need not perform washing and sterilization at the time of use.
  • ・The bag, impeller, shaft, and tube, etc.
    use materials conforming to USP Class VI (United States Pharmacopoeia Class 6).

SUB Series Compatible with Scalable Cell Culture

In biomedical products and regenerative medicine, etc., single use is preferred from the viewpoint of improvement in productivity and prevention of contamination. At SATAKE, we have prepared single-use products in the range of 200 ml to 200 l (we plan to develop up to a maximum of 1000 l) for various cases. Cell culture is implemented in a scalable manner from the laboratory to actual production.

SUB Series Compatible with Scalable Cell Culture

* The 200mL single use bottle is compatible with “VMF Reactor VMF-500 and HiD 4 × 4”.
* The 3L single use bottle is compatible with “VMF Reactor VMF-3000” and also with 2 to 8 devices connected in series as an option.
* Single-use bag is compatible with “VMF Reactor 50L/200L-SUB”.
* For more details, contact our Biotechnology Business Department.

Various materials used in impellers,
bottles, and bags

Materials conforming to USP Class VI (United States Pharmacopoeia Class 6) are used. All these materials have been developed jointly by Japan’s material manufacturers. Since these are Made in Japan, we promise to provide a stable supply at all times.

Sterilized standard bottles and bags

We prepare hard bottles and bags in the range of 200 mL to 200L. Since EOG sterilization for hard bottles, γ sterilization for back has already been performed, you can start using these products as soon as you receive them. We have prepared certification for each lot.

■VMF 50L / 200L-SUB Specifications
Item Specifications
Product name VMF Reactor
Model 50L/ 200L-SUB
Temperature control type Clamp heater method (PI control) with excessive temperature rise prevention function
Linear-motion transmission method Linear shaft drive non-sealing type
Ventilation type Shirasu porous glass (SPG) membrane type / Sintered metal type
Performance Temperature regulation range Room temperature + 5 to 20 ° C (normally set at 37 ° C)
Temperature regulation accuracy ±0.3℃(37℃)
Max. up/down motion amplitude 100 mm
Max. impeller speed 800 mm/s
Function Temperature setting Digital setting
Up/down motion setting Touch panel input
Configuration Band heater 1.5kW
Mixing motor Max. output 800W
Mixing impellers Standard VM100 + VM200
Standard Culture tank dimensions Inner diameter 369×650 Depth [mm]
Culture tank total capacity 75L
Operating ambient temperature range 10~35℃
Outer dimensions 780W×800D×2000H [mm]
Weight Main unit approx. 135 kg, Vessel ASSY approx. 42 kg
Rated power supply Power is supplied from S-BOX × 200

* The performance is the value at a room temperature of 20℃, rated power supply voltage 100 VAC 50 Hz, during no load.

■S-BOX×200Specifications
Item Specifications
Name Culture controller
Model S-BOX×200
Display range / accuracy TH(Temperature) 0.0~150.0[℃]
Linear shaft (mixing) Stroke 0~100[mm] Speed setting 0~800[mm/s]
pH(Hydrogen ion concentration) 0.00~14.00[pH]
DO(Dissolved oxygen) 0.00~10.00[mg/L]
FL(O₂flow rate) 0.0~200.0[mL/min]
Electronic balance (for supply of culture medium) 0.1[g]~61[kg]
Control setting range TH(Temperature) 0.0~60.0[℃]
Linear shaft (mixing) Stroke 0~100[mm] Speed setting 0~300[mm/s]
pH(Hydrogen ion concentration) 0.00~14.00[pH]
DO(Dissolved oxygen) 0.00~10.00[mg/L]
FL(O₂flow rate) 1.0~200.0[mL/min]
Electronic balance (for supply of culture medium) 0.1[g]~61[kg]
Control output TH(Temperature) PI Control (slope set method: Time, %)
Linear shaft (mixing) Fixed-value control by shaft driver
pH(Hydrogen ion concentration) On/Off control by addition of CO₂ gas, and
On/Off control selection type by alkali pump
DO(Dissolved oxygen) Control (slope set method: Time, %)
By mass flow controller
FL(O₂flow rate) PI Control (slope set method: Time, %)
FEED On/Off addition by FEED pump
Culture medium supply / discharge Supply and discharge by electronic balance and discharge pump
Recording medium Data logger 10 ch
Power supply 1Φ 200V 30A 50/60Hz(2P+E、With hook-type plug)
Case material SUS304 #300 Buffing, indoor type, non-drip proof, non-explosion proof specification
Installation method Indoor stand-alone type
Outer dimensions W550×D550×H1000 [mm] *Does not include projections
Ambient environment conditions Temperature Room temperature
Humidity 0~90%(No dew formation)
Utility Power supply 1Φ 200V 30A
(2P + E, electrical outlet for 30 A hook-type plug) × 1 
O₂ Flow rate 5 l/min or less Supply pressure 0.2MPa 
Connection port Φ6 tube one-touch joint
CO₂ Flow rate 5 l/min or less Supply pressure 0.2MPa 
Connection port Φ6 tube one-touch joint
AIR Flow rate 5 l/min or less Supply pressure 0.2MPa 
Connection port Φ6 tube one-touch joint

* O₂, CO₂, and AIR must all be dry gases that do not contain corrosive components, dust, and oil mist