Products & Services

Products & Services


HiD 4×4

3D floating iPS cell differentiation induction BioReactorr

Development, Customization, and Single-use support of Exclusive Reactor in Accordance with Requirements Specifications

HiD 4×4

Patent No. 4316251, Other patents have either being applied for or already registered

The HiD 4 × 4 Reactor is the world’s first “Single-use mixer for 3D floating cell cultures” used exclusively for iPS cell differentiation induction. A BioReactor that achieves a high-volume production of uniform and homogeneous iPS cells is indispensable not only in regenerative medicine, but also in the “Use of human iPS cells in drug development” that aims at industrialization and commercial production. By promoting joint research and development with excellent research institutes or companies in Japan, we have succeeded in commercialization an iPS cell differentiation induction BioReactor for the first time in the world. 4, 8, 12, and 16 (or even more) such BioReactors can be controlled in a consolidated manner, and these are also best suited for screening. Moreover, we have also taken into consideration the adaptation to ES cells while performing development. With the help of the dedicated controller “S-BOX × 02”, changes in various parameters including PI control, and production control in accordance with the purpose can be performed.

single use bottle 200ml

single use bottle 200ml

Various materials used in impellers, bottles, and bags

Materials conforming to USP Class VI (United States Pharmacopoeia Class 6) are used. All these materials have been developed jointly by Japan’s material manufacturers. Since these are Made in Japan, we promise to provide a stable supply at all times even in small lots. There is no need to have a lot of Inventory due to the supply risk caused by overseas products.

Sterilized standard bottles

The bottles have already undergone EOG sterilization.
We have prepared certification for each lot.


In principle, single-use bottles are provided only with a tube. Installation of the pH sensor and DO sensor will be performed in the clean bench. Contact separately if you want a non-contact sensor. We offer several optional products such as the continuous culture medium supply system, supply culture medium 37℃ adjustment system, bags provided as accessories, mechanism for humidity adjustment of gas flowing inside the cell culture tank, etc. We can also comply with special specifications. Please consult us for more details.

■HiD4×4 Specifications
Item Specifications
Product name HiD 4×4
Model HiD 4-4
Temperature control type Hot plate + Chiller overheating cooling method With excessive temperature rise prevention function
Linear-motion transmission method Linear shaft drive non-sealing type
Performance Temperature regulation range Room temperature +5~20℃(normally set to 37℃)
Temperature regulation accuracy ±0.3℃(37℃)
Max. up/down motion amplitude 40mm
Max. impeller speed 500mm/s
Function Temperature setting Digital setting
Up/down motion setting Touch panel input
Configuration Hot plate 235W × 4
Mixing motor Max. output 800W
Mixing impellers Standard VM200
Standard Culture tank dimensions Inner diameter 86(94) × 107 Depth [mm]
Culture tank total capacity 0.7L
Operating ambient temperature range 10~35℃
Outer dimensions Reactor body
680W × 480D× 914H [mm]
Cooling chiller
205W × 405D× 545H [mm]
Weight Reactor body
Approx. 70kg
Cooling chiller
Approx. 28kg
Rated power supply AC-100V 50/60Hz

* The performance is the value at a room temperature of 20℃, rated power supply voltage 100 VAC 50 Hz, during no load.

■S-BOX×02 Specifications
Item Specifications
Name 4-Unit 200 ml culture controller
Model S-BOX×02
Display range / accuracy pH (Hydrogen ion concentration) 0.00~14.00 [pH]
DO (Dissolved oxygen) 0.0~130.0[%]
Control setting range pH (Hydrogen ion concentration) 0.00~14.00 [pH]
DO (Dissolved oxygen) 0.0~130.0[%]
Control output pH (Hydrogen ion concentration) On/Off control by addition of CO₂ gas
DO (Dissolved oxygen) On/Off control by addition of CO₂ gas
Recording medium Data logger 20 ch
Power supply AC100~230V  50/60Hz
Case material SUS304 #300 buffing
Indoor type, non-drip proof, non-explosion proof specification
Installation method Indoor stand-alone type
Outer dimensions W600×D500×H914 [mm] *Does not include projections
Ambient environment conditions Temperature Room temperature
Humidity 20~90%(No dew formation)
Utility Power supply 100 VAC electrical outlet × 2
(For controller main unit, notebook PC) 
O₂ Flow rate 1 l/min or less Supply pressure 0.2 MPa  
Connection port Φ6 tube one-touch joint
CO₂ Flow rate 1 l/min or less Supply pressure 0.2 MPa  
Connection port Φ6 tube one-touch joint
AIR Flow rate 1 l/min or less Supply pressure 0.2 MPa 
Connection port Φ6 tube one-touch joint

* O₂, CO₂, and AIR must all be dry gases that do not contain corrosive components, dust, and oil mist