Products & Services

Products & Services


HiD 4×4

3D floating iPS cell differentiation induction BioReactorr

Development, Customization, and Single-use support of Exclusive Reactor in Accordance with Requirements Specifications

HiD 4×4
The HiD 4 × 4 is the world’s first “Single-use mixer for 3D floating cell cultures” used exclusively for iPS cell differentiation induction. A BioReactor that achieves a high-volume production of uniform and homogeneous iPS cells is indispensable not only in regenerative medicine, but also in the “Use of human iPS cells in drug development” that aims at industrialization and commercial production. By promoting joint research and development with excellent research institutes or companies in Japan, we have succeeded in commercialization an iPS cell differentiation induction BioReactor for the first time in the world. 4, 8, 12, and 16 (or even more) such BioReactors can be controlled in a consolidated manner, and these are also best suited for screening. Moreover, we have also taken into consideration the adaptation to ES cells while performing development. With the help of the dedicated controller “S-BOX × 02”, changes in various parameters including PI control, and production control in accordance with the purpose can be performed.

Single use bottle

This product features a 0.5 L single-use bottle as a standard, making it perfect for upscaling and commercial or industrial production. It is designed not only for safety, but with a focus on usability for more efficient culturing.

single use bottle 0.5 L

Various materials used in impellers, bottles, and bags

Materials conforming to USP Class VI (United States Pharmacopoeia Class 6) are used. All these materials have been developed jointly by Japan’s material manufacturers. Since these are Made in Japan, we promise to provide a stable supply at all times even in small lots. There is no need to have a lot of Inventory due to the supply risk caused by overseas products.

Sterilized standard bottles

The bottles have already undergone EOG sterilization.
We have prepared certification for each lot.
An elution certificate can be provided (at an additional charge) upon request for production specifications.


In principle, single-use bottles are provided only with a tube. Installation of the pH sensor and DO sensor will be performed in the clean bench. Contact separately if you want a non-contact sensor. We offer several optional products such as the continuous culture medium supply system, supply culture medium 37℃ adjustment system, bags provided as accessories, mechanism for humidity adjustment of gas flowing inside the cell culture tank, etc. We can also comply with special specifications. Please consult us for more details.

Dedicated data logger / software

Dedicated data logger / software

Using a dedicated data logger connected to a computer via Ethernet cable and our proprietary software, you can set an interval at which to acquire data on changes over time such as DO, pH, temperature, O2 flow rate, frequency, and number of revolutions during culturing, which can then be saved in CSV format.

Item Specifications
Name HiD4×4
Model HiD4-4
Temp. control device Hot plate + chiller / heating & cooling type (PID control) with over-temperature protection function
Power transmission Linear shaft drive non-sealing type
Performance*1 Temp. control range Room temperature + 5 - 20 [℃] (normally set to 37 [℃])
Temp. accuracy ±0.3 [℃] (37 [℃])
Max. shaft stroke 40 [mm]
Max. shaft speed 150 [mm/s]
Function Temp. setting Touch panel input, data output DC1 - 5 [V]
Vertical motion setting Touch panel input, (option : mixing frequency data output DC0 - 5 [V] )
Configuration Power of hot plate 235 [W]×4
Chiller Cooling type, 450 [W], HFC R-404A
Power of motor Max. output 800 [W]
Mixing impeller VM200
Culture tank Dimensions I.D. 94/87 x Depth 110 [mm]
Culture operation volume 0.25 - 0.3 [L]
Usage condition 10 - 35[℃]
Outer dimensions Main unit (HiD4×4) W680×D480×H914 [mm] Chiller (SCA-32) W205×D405×H545 [mm]
Weight Main unit (HiD4×4) Approx. 70 [kg] Chiller (SCA-32) Approx. 28 [kg]
Power supply AC100 [V], 50/60 [Hz]
*1 The performance is the value under room temperature 20 [℃], power supply AC100 [V], 50 [Hz] and no load condition.

Item Specifications
Name Culture controller
Model S-BOX×02
Control pH, DO (Dissolved oxygen)
Display range/accuracy pH (Hydrogen ion concentration) 0.00 - 14.00 [-] Display accuracy: ±0.5 [%] F.S.
DO (Dissolved oxygen) 0.00 - 20.00 [mg/L]
Setting range pH (Hydrogen ion concentration) 0.00 - 14.00 [-]
DO (Dissolved oxygen) 0.00 - 20.00 [mg/L]
Control type pH (Hydrogen ion concentration) CO2ON/OFF control
DO (Dissolved oxygen) O2ON/OFF control
Data output pH (Hydrogen ion concentration) With data logger DC0 - 5 [V]
(option : Mixing frequencyand Load factor can be outputted.)
Accuracy: ±0.5 [%] F.S.
DO (Dissolved oxygen)
Temperature sensor With data logger DC1 - 5 [V]
MTA of outer surface SUS304 (no coating) , indoor type, non-waterproof, non-explosion proof specification
Installation Indoor stand-alone type
Outer dimensions/weight W600×D500×H914 [mm] *Does not include protrusions approx. 70 [kg]
Usage conditions Temperature 5 - 45 [℃] Humidity 20 - 85 [%] RH (No condensation)
Sensors Polarographic DO sensor/pH sensor manufactured by Mettler Toledo company
(Option: Optical DO sensor manufactured by Automatic System Research Co., Ltd.)
Utilities Power supply AC100 [V], 50/60 [Hz], electrical outlet 2 gang (for main control unit, and laptop)
N2 Flow rate 50 [mL/min] or lower, supply pressure 0.2 [MPa], connection port φ6 one touch tube fitting
O2 Flow rate 50 [mL/min] or lower, supply pressure 0.2 [MPa], connection port φ6 one touch tube fitting
CO2 Flow rate 50 [mL/min] or lower, supply pressure 0.2 [MPa], connection port φ6 one touch tube fitting
AIR Flow rate 150 [mL/min] or lower, supply pressure 0.2 [MPa], connection port φ6 one touch tube fitting
*All of N₂, O₂, CO₂, and AIR must be dry and clean gases that do not contain corrosive components, dust, and oil mist.

Item Specifications
Data gathering
Material Polycarbonate
Outer dimensions W45.1×H111×D107.1[mm]
Weight approx. 0.25[kg]
Power supply From GM90PS power supply module
Power consumption 2.8 [W] or less
Power supply
Material Polycarbonate
Rated voltage AC100-240[V]
Outer dimensions W88×H135×D126.7[mm]
Weight approx. 0.55[kg]
Material Polycarbonate
Outer dimensions W57.7×H135×D103.5[mm]
Weight approx. 0.15[kg]